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Roller bottles are a type of cell culture vessel used in the field of cell biology and biotechnology for the cultivation and expansion of adherent cells. Adherent cells are cells that require a surface to attach and grow, and roller bottles provide a unique environment for their propagation.
Here's an overview of roller bottles in cell culture:
Shape: Roller bottles are typically cylindrical in shape with a horizontal axis. They resemble a soda bottle laid on its side.
Material: They are commonly made of polystyrene or other materials that are suitable for cell culture applications.
Surface Treatment: The inner surface of roller bottles is usually treated to promote cell attachment. This treatment may involve coating the surface with substances like collagen or other extracellular matrix components.
Cell Culture Roller Bottle
Rotation: Roller bottles are mounted on a roller apparatus that continuously rotates them. The rotation ensures a dynamic environment, exposing cells to nutrients and oxygen as they circulate in the medium.
Media Flow: As the roller bottles rotate, the culture medium inside moves in a wave-like fashion. This movement is critical for providing nutrients to the cells and removing waste products.
High Surface Area: Roller bottles offer a large surface area for cell attachment, allowing for the cultivation of a higher number of cells compared to traditional culture flasks.
Low Shear Stress: The rolling motion of the bottles generates low shear stress on the cells, which is beneficial for maintaining the integrity and functionality of certain cell types.
Large-Scale Culture: Roller bottle systems are suitable for large-scale cell culture processes, making them advantageous for industrial production of biological products, such as vaccines or therapeutic proteins.
Uniform Cell Distribution: The rolling motion helps to distribute cells evenly on the culture surface, promoting consistent growth and reducing clumping.
Cell Culture Roller Bottle
Vaccine Production: Roller bottles are commonly used in the production of vaccines, where large quantities of cells are required to produce viral vaccines.
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Monoclonal Antibody Production: The cultivation of hybridoma cells for the production of monoclonal antibodies is another application of roller bottle cell culture.
Virology Studies: Roller bottles are utilized for the propagation of certain types of viruses for virology research.
Cell Type Suitability: Roller bottles are particularly well-suited for adherent cell types. Suspension cells, which do not require a surface for attachment, are typically cultured in alternative vessels.
Media and Conditions: The choice of culture medium and environmental conditions, such as temperature and CO2 levels, should be optimized based on the specific requirements of the cells being cultured.
In summary, roller bottle cell culture is a method used for the large-scale cultivation of adherent cells. The rolling motion of the bottles provides a dynamic environment that supports cell growth and is particularly useful in industrial applications for the production of various biological products.
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Cell culture roller bottles are a common cell culture consumable in the field of life sciences, it is mainly used for culturing and expanding biological cells in vitro. It can provide a large growth surface for cells, and prevent certain components formed in the culture medium from possibly affecting cell growth through slight rotation. In the production of veterinary vaccines, this consumable is mainly used for the cultivation of cells or viruses.
The following are some common examples of cell culture spinner bottles used in veterinary vaccine production:
Swine influenza vaccine: The production of swine influenza vaccine will use cell culture roller bottles to amplify the virus, and extract surface glycoproteins (H and N antigens) from it for vaccine preparation.
Cell Culture Roller Bottles
PRRS Vaccine: This disease was once known as "Mystery Pig Disease", "New Pig Disease", "Porcine Epidemic Abortion and Respiratory Syndrome", "Porcine Reproductive and Respiratory Syndrome", "PRRS", "Pig Plague" and so on, my country has listed it as a second-class infectious disease. The PRRS vaccine is mainly used to prevent this disease.
Porcine circovirus: Taxonomically, it belongs to the genus Circovirus of the Circoviridae family and is one of the smallest known animal viruses. Virus particles have a diameter of 14-17nm, a 20-hedron symmetrical structure, no envelope, and contain a covalently closed single-strand circular negative-strand DNA. The genome size is about 1.76kb. PCV is quite resistant to external physical and chemical factors.
Rabies vaccine: Rabies vaccine is a special drug used to prevent rabies before or after exposure, and post-exposure treatment is the only effective means of preventing rabies after exposure. During the preparation of the rabies vaccine, Vero cells (an African green monkey kidney cell line) are used in cell culture roller bottles to amplify and purify the virus.
Generally speaking, in the production of veterinary vaccines, cell culture roller bottles are widely used in the cultivation of cells or viruses, and are an indispensable tool in the production of veterinary vaccines.
The FAI climbed 5.9 percent year-on-year in the first 11 months of 2018, quickening from the 5.7-percent growth in Jan-Oct, the National Bureau of Statistics (NBS) said Friday in an online statement.
The key indicator of investment, dubbed a major growth driver, hit the bottom in August and has since started to rebound steadily.
In the face of emerging economic challenges home and abroad, China has stepped up efforts to stabilize investment, in particular rolling out measures to motivate private investors and channel funds into infrastructure.
Friday's data showed private investment, accounting for more than 60 percent of the total FAI, expanded by a brisk 8.7 percent.
NBS spokesperson Mao Shengyong said funds into weak economic links registered rapid increases as investment in environmental protection and agriculture jumped 42 percent and 12.5 percent respectively, much faster than the average.
In breakdown, investment in high-tech and equipment manufacturing remained vigorous with 16.1-percent and 11.6-percent increases respectively in the first 11 months. Infrastructure investment gained 3.7 percent, staying flat. Investment in property development rose 9.7 percent, also unchanged.
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